Drug Discov Ther. 2013;7(6):233-242. (DOI: 10.5582/ddt.2013.v7.6.233)
HDAC6: Physiological function and its selective inhibitors for cancer treatment.
Yang PH, Zhang L, Zhang YJ, Zhang J, Xu WF
Acetylation and deacetylation of histones are important in regulating gene expression and play a key role in modification of gene transcription. Specific HDACs isoforms can be regarded as a target for cancer therapy avoiding side-effects, HDAC6 with a unique physiological function and structure has become a hot issue recently. The unique isoform HDAC6 is involved in tumorigenesis, development and metastasis through tubulin, HSP90, invasin and ubiquitin-protein. Here we review the structure elements, biological function, and recent selective inhibitors of HDAC6, and study the structure-activity and structure-selectivity relationship.