Drug Discov Ther. 2012;6(5):238-241. (DOI: 10.5582/ddt.2012.v6.5.238)
A new boronic acid-based fluorescent sensor for L-dihydroxyphenylalanine.
Wu ZY, Yang XY, Xu WF, Wang BH, Fang H
Catecholamines, such as dopamine and L-dihydroxyphenylalanine (L-DOPA), are associated with different physiological functions and diseases. In our recent studies, a novel water-soluble boronic acid compound 3c was identified as a selective fluorescent sensor for L-DOPA. This compound not only has the ability to interact with dopamine and catechol, but also has no fluorescence intensity change for L-DOPA precursors in vivo, such as L-tyrosine.
KEYWORDS: Boronic acid, fluorescent chemosensor, L-DOPA, dopamine