Drug Discov Ther. 2012;6(2):62-68. (DOI: 10.5582/ddt.2012.v6.2.62)

A facile method for the synthesis of N-(α-aminoacyl) sulfonamides.

Wu SL, Chen ML, Wang YT, Hou XB, Yang XY, Su L, Fang H


N-Acylsulfonamide derivatives have important applications in organic synthesis and drug discovery. It was found that many problems occurred preparing amino acid derived N-acylsulfonamides with the commonly used coupling approach in our previous studies. In this paper, we report an efficient approach to synthesize various amino acids derived N-acylsulfonamides in high yields without any racemization.

KEYWORDS: Synthesis, amino acid-derived N-acylsulfonamides, the mixed anhydride method

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