Drug Discov Ther. 2011;5(6):306-310. (DOI: 10.5582/ddt.2011.v5.6.306)

In vitro bactericidal activity against periodontopathic bacteria by electrolyzed ion-reduced water.

Okajima M, Kanzaki M, Ishibashi Y, Wada Y, Hino F, Kitahara Y, Shimokawa K, Ishii F


As typical periodontopathic bacteria, Porphyromonas gingivalis (P. gingivalis) and Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) were exposed to electrolyzed ion-reduced water (ERI) and ERI containing 1% sodium carboxymethylcellulose (CMC-Na) (ERI-1% CMC-Na), and the time course of their bactericidal action was evaluated. More than 99% of each bacteria species were killed after exposure to each solution for 15 sec. In addition, 1% CMC-Na, which was added to prolong bactericidal action, did not affect the bactericidal action of ERI. Its bactericidal action was concentration-dependent. No viable P. gingivalis bacteria were observed at a concentration of 15% of the undiluted solution and no viable A. actinomycetemcomitans bacteria were observed at a concentration of 50%, indicating differences in the bactericidal action of ERI for the two bacteria species. These results suggest that ERI may be extremely useful in preventing and treating periodontal diseases.

KEYWORDS: Electrolyzed ion-reduced water, functional electrolyzed alkaline water, functional electrolyzed water, periodontopathic bacteria, bactericidal activity

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