Drug Discov Ther. 2020;14(2):100-102. (DOI: 10.5582/ddt.2020.03006)

Treat 2019 novel coronavirus (COVID-19) with IL-6 inhibitor: Are we already that far?

Zhang YY, Zhong YY, Pan L, Dong J


The world is in the midst of the coronavirus disease 2019 (COVID-19) pandemic. Interleukin 6 (IL-6) inhibitor (tocilizumab) had been suggested for the treatment of acute respiratory distress syndrome (ARDS) patients based on the concept of "cytokine storm" in COVID-19. However, we still lack reliable studies to verify "cytokine storm" in COVID-19 pneumonia. Furthermore, IL-6 inhibitor has potential hazards of inducing infectious diseases. The efficacy of IL-6 monoclonal antibody-directed therapy remains to be fully evaluated.

KEYWORDS: coronavirus, cytokine storm, pneumonia, tocilizumab

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