Drug Discov Ther. 2017;11(5):291-292. (DOI: 10.5582/ddt.2017.01039)

Early small bowel perforation due to aflibercept.

Moussalem T, Lim C, Osseis M, Esposito F, Lahat E, Fuentes L, Salloum C, Azoulay D


In patients with malignancy who receive aflibercept based chemotherapy, gastrointestinal perforation is among the reported adverse events with a prevalence of 1.9%. This complication may lead to mortality up to 10.8%. We here report a case of small bowel perforation that occurred fifteen days after the first cycle of aflibercept in a 58-year old female who had metachronous colorectal liver metastases. Emergency laparotomy was performed and revealed a small bowel perforation without any anastomotic dehiscence. Surgery was followed by uneventful outcome. The use of aflibercept in patients with malignancy may be associated with very early gastrointestinal perforation and this should be known by oncologist and surgeons.

KEYWORDS: Aflibercept, chemotherapy, gastrointestinal, perforation, angiogenesis inhibitor

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