Drug Discov Ther. 2016;10(1):57-61. (DOI: 10.5582/ddt.2016.01025)
Acute oral toxicity test of chemical compounds in silkworms.
Usui K, Nishida S, Sugita T, Ueki T, Matsumoto Y, Okumura H, Sekimizu K
This study performed an acute oral toxicity test of 59 compounds in silkworms. These compounds are listed in OECD guidelines as standard substances for a cytotoxicity test, and median lethal dose (LD50) were calculated for each compound. Acute oral LD50 values in mammals are listed in OECD guidelines and acute oral LD50 values in silkworms were determined in this study. R2 for the correlation between LD50 values in mammals and LD50 values in silkworms was 0.66. In addition, the acute oral toxicity test in silkworms was performed by two different facilities, and test results from the facilities were highly reproducible. These findings suggest that an acute oral toxicity test in silkworms is a useful way to evaluate the toxicity of compounds in mammals.