Drug Discov Ther. 2016;10(1):24-29. (DOI: 10.5582/ddt.2016.01012)
Identification of lysocin E using a silkworm model of bacterial infection.
Hamamoto H, Sekimizu K
New antimicrobials with novel mechanisms need to be developed to combat antimicrobial-resistant pathogenic bacteria. The current authors recently reported discovery of a new antibiotic named "Lysocin E". Lysocin E was identified using a silkworm model of bacterial infection. The current review discusses the advantages of using a silkworm model of bacterial infection to identify and develop therapeutically efficacious antimicrobials. This review also discusses the discovery of lysocin E and its novel mechanism of action.
KEYWORDS: Antimicrobial, lysocin E, silkworm, multidrug-resistant pathogens