Drug Discov Ther. 2016;10(1):14-18. (DOI: 10.5582/ddt.2016.01016)

A hyperglycemic silkworm model for evaluating hypoglycemic activity of Rehmanniae Radix, an herbal medicine.

Matsumoto Y, Sekimizu K


Silkworm shows hyperglycemia after intake of diet containing large amount of glucose. The hyperglycemic silkworm model is useful for evaluation of anti-diabetic drugs. A hot water extract of Rehmanniae Radix, an herbal medicine, showed hypoglycemic effect against the hyperglycemic silkworms. This method is applicable for quick and simple evaluation of the hypoglycemic activities of different batches of Rehmanniae Radix. Our findings suggest that silkworms have a lot of merit as experimental animals for evaluation of various herbal medicines.

KEYWORDS: Hyperglycemia, silkworm, in vivo evaluation system, Rehmanniae Radix, quality check

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