Drug Discoveries & Therapeutics

Drug Discoveries & Therapeutics is a new international peer-reviewed journal. Drug Discoveries & Therapeutics publishes articles in all fields of basic and clinical pharmaceutical research including pharmaceutical and therapeutical chemistry, pharmacology, pharmacy, pharmacokinetics, industrial pharmacy, pharmaceutical manufacturing, pharmaceutical technology, drug delivery, toxicology, and traditional herb medicine.

Abstract

Drug Discov Ther. 2010 ;4(3):208-216.

Optimization and characterization of diclofenac sodium microspheres prepared by a modified coacervation method.
El-Leithy ES, Shaker DS, Ghorab MK, Abdel-Rashid RS

ABSTRACT: A modified coacervation method for preparing diclofenac sodium loaded chitosan (DFS-C) microspheres, using sodium citrate as cross-linking agent was optimized. A full 2³ factorial design was used to evaluate the effect of chitosan (CS) concentration, cross-linking agent concentration, and cross-linking time on the properties of the prepared microspheres. The modified coacervation method resulted in higher yield of spherical microspheres even with a lower concentration of CS (0.3%, w/v). The morphology of the microspheres was found to be dependent on the formulation and process parameters. The cross-linking agent concentration had the largest impact on swelling, mucoadhesion, and drug release. Kinetic analysis of the release data revealed a quasi-Fickian diffusion mechanism.

Key Words: Diclofenac sodium, chitosan microspheres, modified coacervation, factorial design

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